She Hulk and her "Gamma Wedgies" from several comic books.

Some superheroes have special moves but very few of them create scenarios for embarrassment or humiliation. However, the lovely She-Hulk seems to be a very cheeky character and apparently has a recurring joke move called "the gamma wedgie." Its a regular wedgie that becomes painful on the receiver (always male) because of Shulkie's incredible power.

In The Marvelous Adventure of Gus Breezer: Hulk. She Hulk gives The Hulk a painful gamma wedgie as a prank for laughing at her suggestion that she is stronger than her.

A mention of the technique occurs in the second issue of Spider-Man and the Fantastic Four. She-Hulk won't put up with Johnny's juvenile pranks, she is gonna have to get juvenile as well, so she threatens him with one of her gamma wedgies. 

In Thing & She-Hulk: The Long Night. She-Hulk humiliates a bunch of dumb guys who catcalled her on public transportation. One of them was de-pantsed and another one has an atomic melvin type of wedgie.

I remember She-Hulk giving another male enemy a wedgie at one point but I can't remember the name of the comic. Due to the comedic nature of her stories, She-Hulk is one of the few female characters with a playful side to her and it's always welcomed. Would also be nice to see her give a female villain one of her classic gamma wedgies at one point. 

The Legend of Tarzan: Tarzan ends up naked in front of Jane - CFNM + Underwear moment

In the third episode of The Legend of Tarzan titled The Lost Cub, Tarzan finds an adorable little leopard cub. In one scene, the little fella steals Tarzan's loincloth and runs away, leaving him completely naked while shamefully covering his privates. Jane finds this amusing and giggles at the naked guy.

As a bonus, I have a small male underwear moment. In the episode The new wave, one of Jane's friends finds a pair of boxers, these belong to Jane's father. You can see it in the video above.

Archie's Weird Mysteries: Pantsing (CFNM)

In the fourth episode of Archie's Weird Mysteries, titled Invisible Archie, Reggie turns invisible and decides to humiliate a jock who is getting attention from the girls. He walks up to him thinking he's invisible and pulls down his pants, revealing his white boxers with blue hearts on them. This makes Veronica gasp at the scene while Betty giggles at the embarrassed guy. 

Balls of Fury: Pantsing - EUM (CFNM)

In the comedy sports movie Balls of Fury, the typical "action girl sidekick to the main guy" stereotype in action and adventure movies is introduced. She shows off her skills by beating up a bunch of guys and pulls down the pants of one of them, revealing his tighty whities.

Another example of an action heroine humiliating a male enemy.

G.I Joe: Lady Jaye loses her pants (EUF)

Few American cartoons in the eighties ever got to have moments of comedic underwear exposure with female characters due to the great censorship they faced but somehow this episode from season 2 of G.I Joe titledGrey Hairs and Growing Pains managed to pass without changes or problems.

In the episodes, the main characters are turned into younger versions of themselves by the villains, including Lady Jaye, who loses her pants when a robot attacks her, once they all grow back she hides pantless and asks for help slightly embarrassed. She was previously shown wearing normal white underpants.