Archie's Weird Mysteries: Pantsing (CFNM)

In the fourth episode of Archie's Weird Mysteries, titled Invisible Archie, Reggie turns invisible and decides to humiliate a jock who is getting attention from the girls. He walks up to him thinking he's invisible and pulls down his pants, revealing his white boxers with blue hearts on them. This makes Veronica gasp at the scene while Betty giggles at the embarrassed guy. 

G.I Joe: Lady Jaye loses her pants (EUF)

Few American cartoons in the eighties ever got to have moments of comedic underwear exposure with female characters due to the great censorship they faced but somehow this episode from season 2 of G.I Joe titledGrey Hairs and Growing Pains managed to pass without changes or problems.

In the episodes, the main characters are turned into younger versions of themselves by the villains, including Lady Jaye, who loses her pants when a robot attacks her, once they all grow back she hides pantless and asks for help slightly embarrassed. She was previously shown wearing normal white underpants.

Scooby Doo 2: Monster Unleashed (EUM)

Not everyday you get to see a zombie wearing tighty whities. In the second Scooby-Doo movie, real monsters wreak havoc around the city and the gang gets to fight them. At the end of the movie, it's up to Scooby to turn on a machine that will defeat the monsters, in the process, he takes care of the monsters one by one. 

This includes dashing between the legs of the zombie and ripping the back of his pants, revealing a pair of old worn out briefs. The monster covers himself in embarrassment. 

A great little moment that shows a cartoon character humiliating an enemy by exposing his uncool undies to the world.

Video:

The Secret Files of the Spy Dogs: Episode 1 (EUF)

A small and very obscure moment from a very unsuccessful and obscure cartoon. I knew nothing about this show before the clip was posted and became famous among the community. 

It's a standout clip for three reasons: One, it's an EUF clip from a forgotten cartoon and it's rather explicit. Two, it features a postwoman being humiliated by a dog, a role usually given to male characters especially if it features such humiliating moments. Three, it's an example of women in cartoons wearing boxers instead of panty briefs that are commonly associated with women's underwear.

I liked it because of all those reasons and because of the artstyle itself, not to mention, it's a funny moment.

The scene takes place at the end of the episode when we are shown an example of "dogs being dogs" and of course one of the things dogs like to do the most is to bite the pants of mail carriers. So, we see a small dog come after a postwoman from behind and bite her shorts, pulling them down in the process, exposing her purple boxers with dots on them. 

Maybe it's an instance of TV censorship having a problem with smaller underwear on women, since female comedic moments are few to begin with, maybe the people making these tv shows get stuff approved by making them wear bloomers, nightgowns, boxers and such. Thankfully, that's not an issue anymore, even if they were creative choices for underpants. Maybe this also works as boxer lady representation since a lot of women do wear boxers sometimes. Either way it's a great clip.

Full video:

Here's a spanish version I found (en español):

Spongebob Squarepants- Hooky (EUM-ENM)

One of the most famous scenes of humiliation in animation. The season one episode of Spongebob Squarepants titled Hooky features the main character disobeying his boss and playing around with seemingly deadly hooks he and Patrick found that morning. 

Spongebob and Patrick don't listen to the warnings by Mr. Crabs and they eventually end up paying for it. The boys have their fun but soon enough Patrick gets hooked and he is then taken to the surface. Spongebob isn't aware of this but is worried when Patrick disappears. 

The poor Sponge decides to leave but he notices that one of the hooks is stuck to his clothing. He panics and decides to run for help. Once he arrives at the Krusty Krab he has to confess to his boss about playing with the hooks. He is then told that there is only one way to release himself, Spongebob then realizes that this means he will have to take off his pants, in front of a group of girls no less (Pearl the whale and her friends were having a party there).

They will turn him into tuna if he gets hooked.

Sorry, lad. But theres only one thing you can do.

The hook pulls Bob away but he manages to fight it and decides to reluctantly take his pants off, revealing his usual pair of tighty whities. Mr. Crabs then points out one major problem: Bob's underpants are also hooked!

Bob decides that humiliation is enough and refuses to take his underwear off. Mr. Crabs tells him that he will have to, he's otherwise doomed and he will have to get a new cook. 

The hook then pulls Bob even harder by his undies but the boy manages to grab onto a sign as his panties are pulled.

He cries and complains in complete embarrassment and desperation. His underwear can't stand for long and the briefs are ripped right off.

Off with the undies.

He sighs in relief but the sign catapults him into the glass window of the restaurant. Bob crashes on the window, completely naked, Pearl and her group of female friends start to laugh at his state. Pear l then says the classic line "Look, it's Spongebob Nudiepants!", making fun of his name and his nakedness.

The girls laugh at the naked Bob.

Bob shrieks in humiliation after blushing and promptly runs away covering his privates, completely butt-naked, all the way to his house.

The "run of shame"

It was really just Squidward all along. Here he is holding the hook with Spongebob's ripped briefs.

A great scene that completely degrades Spongebob, not only is he caught disobeying the advice of an older and wiser person, but he is also slowly stripped out of his clothes infront of girls, who have no shame in giggling at the naked laughingstock. 

Heres a video version of the last scene but you should watch the full episode to get the full display of embarrassment: